Concurrent TMS-EEG to characterize cortical responses in the motor and prefrontal cortices in Parkinson's disease

Lin Zhu; Min Cai; Zian Pei; Xue Shi; Ge Dang; Xiaoyong Lan; Xiaoguang Luo; Xianwei Che; Yi Guo

doi:10.1016/j.neurot.2025.e00577

Concurrent TMS-EEG to characterize cortical responses in the motor and prefrontal cortices in Parkinson's disease

Neurotherapeutics. 2025 Apr 16:e00577. doi: 10.1016/j.neurot.2025.e00577. Online ahead of print.

Authors

Lin Zhu¹, Min Cai², Zian Pei³, Xue Shi¹, Ge Dang¹, Xiaoyong Lan⁴, Xiaoguang Luo¹, Xianwei Che⁵, Yi Guo⁶

Affiliations

¹ Department of Neurology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
² Department of Neurology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China; Henan Key Laboratory of Neurorestoratology, Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
³ Department of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen, China.
⁴ Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
⁵ Centre for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
⁶ Department of Neurology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China; Shenzhen Bay Laboratory, Shenzhen, Guangdong, China. Electronic address: guoyi@szbl.ac.cn.

PMID: 40246612
DOI: 10.1016/j.neurot.2025.e00577

Abstract

Patients with Parkinson's disease (PD) experience both motor and non-motor symptoms. However, it remains unclear the full spectrum of PD, which requires a comprehensive assessment of both motor and non-motor cortical regions. The use of combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) allows the examination of neural circuit beyond motor cortex. In this study, TMS-EEG data were collected over the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) in 46 patients with PD and 27 healthy controls (HC). We analyzed TMS-evoked potentials and oscillatory powers to identify differences in cortical excitability and neural connectivity dynamics between the two cohorts. Patients with PD exhibited higher P30 amplitude following M1 stimulation compared to HCs, and there was a positive correlation between P30 amplitude and the severity of motor symptoms. DLPFC stimulation revealed an increased global mean field amplitude area under the curve (GMFA-AUC) at P30 and P60 in the PD group compared to HCs. A significant correlation was also observed within the PD group between P30 and P60 with depression scores. In addition, PD showed a significant power reduction in the alpha and beta bands during stimulation and distinct patterns emerged for each stimulation site. These findings provide novel insights into cortical network abnormalities and contribute to a better understanding of the mechanisms underlying PD.

Keywords: Electroencephalography (EEG); Motor and prefrontal cortex; Oscillatory responses; Parkinson's disease (PD); Transcranial magnetic stimulation (TMS).