Clinical Validity of Autosomal Dominant ALPK3 Loss-of-Function Variants as a Cause of Hypertrophic Cardiomyopathy

Affiliations

• ¹ Genomics and Inherited Disease Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia (S.H., F.S., J.I.).
• ² Faculty of Medicine and Health (S.H., E.S.S., B.G., C.S., R.D.B.), The University of Sydney, New South Wales, Australia.
• ³ Centenary Institute (E.S.S., C.S., R.D.B.), The University of Sydney, New South Wales, Australia.
• ⁴ Division of Cardiovascular Medicine, Department of Medicine, Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, CA (C.R., V.P.).
• ⁵ Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD (B.M., B.A., E.E.B., C.A.J.).
• ⁶ Division of Human Genetics, Department of Internal Medicine, Ohio State University, Columbus (E.J., R.E.H.).
• ⁷ Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.C., A.O., L.H.-A.).
• ⁸ Department of Cardiology and Genomic Medicine, Royal Melbourne Hospital, Victoria, Australia (S.P.).
• ⁹ Department of Genetics, University of North Carolina at Chapel Hill (M.M., A.W., E.O., C.T.).
• ¹⁰ Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia (B.G., C.S.).
• ¹¹ Predictiv Care, San Francisco, CA (M.-L.A.).
• ¹² Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle (K.A.).
• ¹³ Department of Pathology and Laboratory Medicine (L.B.), University of Ottawa, Canada.
• ¹⁴ Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Canada (L.B., O.J.).
• ¹⁵ Department of Biomolecular Medicine, Ghent University, Belgium (B.C.).
• ¹⁶ Center for Medical Genetics (B.C., L.M.-M.), Ghent University Hospital, Belgium.
• ¹⁷ Center for Inherited Cardiovascular Diseases, WellSpan Health, Lancaster, PA (C.A.A.C.).
• ¹⁸ Mayo Clinic, Rochester, MN (C.A.A.C.).
• ¹⁹ Barts Heart Centre and William Harvey Research Institute, Queen Mary University of London, United Kingdom (C.A.A.C.).
• ²⁰ Children's Hospital of Eastern Ontario Research Institute (O.J.), University of Ottawa, Canada.
• ²¹ Division of Cardiology, Department of Pediatrics, Duke University School of Medicine, Durham, NC (A.P.L.).
• ²² Department of Medicine (Cardiology), Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (E.M.M.).
• ²³ Division of Pediatric Cardiology, Department of Pediatrics (L.M.-M.), Ghent University Hospital, Belgium.
• ²⁴ Heart Center and Department of Experimental Cardiology, Amsterdam University Medical Center, Amsterdam Cardiovascular Sciences, University of Amsterdam, the Netherlands (R.W.).
• ²⁵ Clinical Genomics, Ambry Genetics, Aliso Viejo, CA (B.W.).
• ²⁶ National Heart and Lung Institute and Medical Research Council (MRC) Laboratory of Medical Science, Imperial College London, United Kingdom (J.S.W.).
• ²⁷ Royal Brompton, Harefield Hospitals, Guy's & St Thomas' National Health Service (NHS) Foundation Trust, London, United Kingdom (J.S.W.).
• ²⁸ Department of Anatomy and Physiology, University of Melbourne, Victoria, Australia (B.L.P.).
• ²⁹ Murdoch Children's Research Institute and Melbourne Center for Cardiovascular Genomics and Regenerative Medicine, The Royal Children's Hospital, Parkville, Victoria, Australia (E.R.P., D.A.E., J.W.M.).
• ³⁰ Faculty of Medicine and Health, School of Clinical Medicine, University of New South Wales Sydney, Sydney, Australia (J.I.).