Assessing the impact of biosecurity compliance on farmworker and livestock health within a one health modeling framework

Arash Arjmand; Majid Bani-Yaghoub; Kiel Corkran; Pranav S Pandit; Sharif S Aly

doi:10.1016/j.onehlt.2025.101023

Assessing the impact of biosecurity compliance on farmworker and livestock health within a one health modeling framework

One Health. 2025 Apr 2:20:101023. doi: 10.1016/j.onehlt.2025.101023. eCollection 2025 Jun.

Authors

Arash Arjmand¹, Majid Bani-Yaghoub¹, Kiel Corkran¹, Pranav S Pandit^{2

3}, Sharif S Aly³

Affiliations

¹ Division of Computing, Analytics & Mathematics, School of Science and Engineering, University of Missouri, Kansas City, MO, USA.
² EpiCenter for Disease Dynamics, One Health Institute, School of Veterinary Medicine, University of California Davis, One Shields Ave, CA 95616, USA.
³ Department of Population Health and Reproduction, University of California, Davis School of Veterinary Medicine, Davis, California, United States of America.

Abstract

Biosecurity compliance refers to adherence to protocols aimed at preventing infectious disease outbreaks and controlling antimicrobial resistance (AMR) across human, animal, and environmental interfaces. While many models focus solely on animal health, this study develops a One Health modeling framework to assess the impact of different compliance levels on both animal and farmworker health. The model integrates Ordinary Differential Equations (ODE) for pathogen transmission in animals and the environment with Stochastic Differential Equations (SDE) for disease spread among farmworkers. The next-generation matrix approach estimates the basic reproduction number $(R_{0}^{(i)})$ specific to each pathogen strain $i$ , identifying thresholds for outbreaks or elimination of infection. Using literature-derived data on Salmonella transmission dynamics, the model is validated, and key parameters values are estimated. Using the calibrated model, we examine infection transmission in dairy cattle and zoonotic spillover to farmworkers with a focus on five key biosecurity measures: (1) animal movement control and quarantine, (2) disease monitoring and reporting, (3) hygiene and disinfection, (4) feeding and watering practices, and (5) antimicrobial stewardship. Simulations reveal that compliance with biosecurity measures that reduce host-to-host transmission in the animal population has the highest impact on the reduction of infection both in animal and farmworker populations. Further ODE-SDE model analysis indicates that full compliance with the other biosecurity measures is insufficient to prevent outbreaks in a dairy farm. These results are consistent with the local and global sensitivity analyses of the model. The One Health modeling framework developed in this study can also be applied to other zoonotic diseases as a guiding tool for decision making and optimal resource allocation to reduce the likelihood of spillover.

Keywords: Basic reproduction number; Biosecurity compliance; Farmworker; Livestock; Spillover; Stochastic differential equations.