Choroid plexus: Insights from distinct epithelial cellular components

Valentina Scarpetta; Kim Hoa Ho; Marleen Trapp; Annarita Patrizi

doi:10.1016/j.conb.2025.103028

Choroid plexus: Insights from distinct epithelial cellular components

Curr Opin Neurobiol. 2025 Apr 22:93:103028. doi: 10.1016/j.conb.2025.103028. Online ahead of print.

Authors

Valentina Scarpetta¹, Kim Hoa Ho², Marleen Trapp³, Annarita Patrizi⁴

Affiliations

¹ Schaller Research Group, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin 10126, Italy.
² Schaller Research Group, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg 69120, Germany.
³ Schaller Research Group, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
⁴ Schaller Research Group, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Interdisciplinary Center for Neuroscience, Heidelberg University, Heidelberg 69120, Germany. Electronic address: a.patrizi@dkfz.de.

PMID: 40267629
DOI: 10.1016/j.conb.2025.103028

Abstract

The choroid plexus (ChP) serves as a vital interface between blood and cerebrospinal fluid (CSF), playing a pivotal role in central nervous system (CNS) development and communication with the body. This review mainly summarizes how the ChP epithelial cells respond to physiological and pathological stimuli, emphasizing the role of distinct organelles and key molecular signaling pathways. Additionally, we discuss the roles of ChP cilia, an evolutionary conserved organelle whose function is still under investigation. Understanding these processes is essential for elucidating how ChP function modulates intrinsic and extrinsic stimuli, which are crucial for maintaining CNS and body homeostasis.

Publication types

Review