Objectives: To determine the area under curve (AUC) for vasoactive ventilation renal score (VVRS) > 10 at 24-h of admission for predicting mortality in children aged 1-12 years admitted to pediatric intensive care unit (PICU). To also determine the AUC for VVRS > 10 at 48-h of admission for predicting mortality and to determine the AUC of VVRS > 10 at 24-h and 48-h of admission for predicting PICU stay > 3 days, hospital stay > 10 days and mechanical ventilation > 3 days.
Methods: This observational study included 310 children aged 1-12 years admitted in PICU. All required parameters were noted, and VVRS, ventilation index and change in creatinine at 24-h and 48-h of admission were recoded. Receiver operating characteristic curves were computed to determine the predictive role of VVRS > 10 at 24-h and 48-h for mortality, duration of PICU stay, hospital stay and mechanical ventilation.
Results: Seventy nine (25%) patients succumbed during the study. VVRS > 10 at 24-h and 48-h had a good predictive role for mortality with AUC of 0.873 (sensitivity 89.87%, specificity 69.70%) and 0.996 (sensitivity 96.20%, specificity 96.10%), respectively. Best cutoffs derived for VVRS (24-h), and VVRS (48-h) were > 2.5 and > 13.5. A higher AUC, sensitivity and specificity of VVRS at 48-h were observed for predicting prolonged PICU stay, duration of mechanical ventilation and hospital stay.
Conclusions: VVRS at 24-h and 48-h has a good predictive role for mortality in children admitted to PICU.
Keywords: Children; Intensive care unit; Outcomes; VVRS.
© 2025. The Author(s), under exclusive licence to Indian Academy of Pediatrics.