Intratumoral Heterogeneity of Mismatch Repair Status and Outcome of Treatment With Dostarlimab in a Patient With Locally Advanced Rectal Adenocarcinoma

Asaf Maoz; Ronald Bleday; Jeffrey Goldsmith; Shanna A Matalon; Mark S Redston; Molly Nestor; Jonathan A Nowak; Matthew B Yurgelun

doi:10.1200/PO-25-00041

Intratumoral Heterogeneity of Mismatch Repair Status and Outcome of Treatment With Dostarlimab in a Patient With Locally Advanced Rectal Adenocarcinoma

JCO Precis Oncol. 2025 Apr:9:e2500041. doi: 10.1200/PO-25-00041. Epub 2025 Apr 28.

Authors

Asaf Maoz^{1

2

3}, Ronald Bleday^{1

2

3}, Jeffrey Goldsmith^{3

4}, Shanna A Matalon^{1

2

3}, Mark S Redston^{1

2

3}, Molly Nestor¹, Jonathan A Nowak^{2

3}, Matthew B Yurgelun^{1

2

3}

Affiliations

¹ Dana-Farber Cancer Institute, Boston, MA.
² Brigham and Women's Hospital, Boston, MA.
³ Harvard Medical School, Boston, MA.
⁴ Boston Children's Hospital, Boston, MA.

PMID: 40294354
DOI: 10.1200/PO-25-00041

No abstract available