Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae

Adriana Cabrera; Emily Mason; Liam P Mullins; Manish Sadarangani

doi:10.1038/s44259-025-00100-8

Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae

NPJ Antimicrob Resist. 2025 Apr 28;3(1):34. doi: 10.1038/s44259-025-00100-8.

Authors

Adriana Cabrera^#^{1

2}, Emily Mason^#^{1

2}, Liam P Mullins^#^{1

2}, Manish Sadarangani^{3

4}

Affiliations

¹ Experimental Medicine Program, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
² Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
³ Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada. msadarangani@bcchr.ubc.ca.
⁴ Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. msadarangani@bcchr.ubc.ca.

^# Contributed equally.

Abstract

Antimicrobial-resistant Enterobacteriaceae are increasingly a clinical challenge. In particular, extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae threaten public health. Vaccination presents a long-term strategy to reduce both drug-susceptible and resistant infections while maintaining current clinical therapies. The review aims to emphasize the need for vaccines targeting extraintestinal pathogenic E. coli and K. pneumoniae by providing an overview of disease burden, antimicrobial resistance, therapeutics, and vaccine development.

Publication types

Review