18F-FDG PET/CT in NUT Carcinoma of the Thorax

Anselm Johannes Schlemmer; Gregor Gorkiewicz; Martin Michael Uggowitzer; Spela Salamon; Philipp Jost; Emina Talakic

doi:10.1097/RLU.0000000000005872

18F-FDG PET/CT in NUT Carcinoma of the Thorax

Clin Nucl Med. 2025 Apr 30. doi: 10.1097/RLU.0000000000005872. Online ahead of print.

Authors

Anselm Johannes Schlemmer¹, Gregor Gorkiewicz², Martin Michael Uggowitzer^{1

3}, Spela Salamon³, Philipp Jost⁴, Emina Talakic¹

Affiliations

¹ Division of General Radiology, Department of Radiology, Medical University of Graz.
² Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz.
³ Division of Radiology and Nuclear Medicine, State Hospital Hochsteiermark, Leoben.
⁴ Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

PMID: 40302130
DOI: 10.1097/RLU.0000000000005872

Abstract

NUT carcinoma (NUTc) is a rare, aggressive cancer characterized by rearrangement of the NUTM1 gene on chromosome 15q14. We present the case of a 32-year-old man with a persisting cough, reduced general condition, and B symptoms for 2 months. CT imaging revealed a highly suspicious mass in the right lung, infiltrating hilar structures, and the mediastinum. Staging with 18F-FDG PET/CT demonstrated pathologic 18F-FDG uptake within the tumor. Histology, immunohistochemistry, and molecular analysis confirmed NUTc of the lung. Metabolic imaging modalities may play a key role in staging, restaging, and assessing treatment response in patients with NUTc.

Keywords: NUT carcinoma; PET/CT; thorax.