[Calcified chondroid mesenchymal neoplasm of the hand: report of a case]

H X Yang; L H Gong; J Liu; L Jiang; S X Wang

doi:10.3760/cma.j.cn112151-20241128-00794

[Calcified chondroid mesenchymal neoplasm of the hand: report of a case]

Zhonghua Bing Li Xue Za Zhi. 2025 May 8;54(5):533-536. doi: 10.3760/cma.j.cn112151-20241128-00794.

[Article in Chinese]

Authors

H X Yang¹, L H Gong², J Liu³, L Jiang³, S X Wang³

Affiliations

¹ The Second School of Clinical Medicine of Binzhou Medical University, Yantai 264100, China Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, China.
² Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
³ Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, China.

PMID: 40302587
DOI: 10.3760/cma.j.cn112151-20241128-00794

Abstract

钙化性软骨样间叶性肿瘤（calcified chondroid mesenchymal neoplasm，CCMN）是新近命名的肿瘤类型，具有独特的临床病理和分子遗传学特征。本文报道1例71岁女性患者手部CCMN。组织学形态显示肿瘤呈多结节分叶状生长，富含黏液软骨样基质。肿瘤中央见成熟软骨伴显著钙化，钙化呈粗颗粒样及散在蕾丝样；周边见卵圆形及梭形细胞增生于纤维及黏液样间质中。荧光原位杂交检测显示FN1基因断裂。二代测序显示FN1：：FGFR1融合。认识到该肿瘤的形态学特征，并结合分子检测技术，可与其他软骨性或伴有软骨样基质的肿瘤鉴别，避免误诊。.

Publication types

Case Reports

MeSH terms

Aged
Calcinosis* / metabolism
Calcinosis* / pathology
Diagnosis, Differential
Female
Hand* / pathology
Humans
In Situ Hybridization, Fluorescence
Mesenchymoma* / genetics
Mesenchymoma* / metabolism
Mesenchymoma* / pathology
Mesenchymoma* / surgery
Receptor, Fibroblast Growth Factor, Type 1 / genetics
Receptor, Fibroblast Growth Factor, Type 1 / metabolism
Soft Tissue Neoplasms* / genetics
Soft Tissue Neoplasms* / metabolism
Soft Tissue Neoplasms* / pathology
Soft Tissue Neoplasms* / surgery

Substances

Receptor, Fibroblast Growth Factor, Type 1
FGFR1 protein, human