Autonomously Functioning Thyroid Nodule With 99mTc-PSMA Uptake in a Patient With Prostate Cancer

Mohammad Hadi Samadi; Pegah Sahafi; Mohammad Ahmadi; Susan Khezri; Somaye Barashki

doi:10.1097/RLU.0000000000005853

Autonomously Functioning Thyroid Nodule With 99mTc-PSMA Uptake in a Patient With Prostate Cancer

Clin Nucl Med. 2025 Apr 30. doi: 10.1097/RLU.0000000000005853. Online ahead of print.

Authors

Mohammad Hadi Samadi¹, Pegah Sahafi¹, Mohammad Ahmadi¹, Susan Khezri², Somaye Barashki¹

Affiliations

¹ Nuclear Medicine Research Center, Mashhad University of Medical Science.
² Department of Internal Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 40310014
DOI: 10.1097/RLU.0000000000005853

Abstract

We present the findings of a 99mTc-PSMA scan in a 76-year-old man with a history of prostate cancer. He was referred for re-staging and response to treatment. The 99mTc-HYNIC PSMA scan incidentally detected an area of increased uptake in the neck region. Subsequent SPECT/CT imaging revealed a large, heterogeneous PSMA-avid thyroid nodule with macrocalcification, suggesting a benign thyroid nodule. Comprehensive imaging confirmed hyperthyroidism with a large autonomously functioning nodule. The case underscores the importance of recognizing PSMA uptake in benign thyroid lesions, emphasizing the need for a thorough evaluation to prevent misdiagnosis and ensure appropriate management.

Keywords: SPECT/CT; autonomously functioning thyroid nodule; prostate adenocarcinoma; thyroid incidentaloma.