Green hydrogen production via proton exchange membrane water electrolysis (PEMWE) faces economic feasibility challenges, primarily due to its reliance on noble metal catalysts. While cost-effective Ru-based catalysts show promise as alternatives to expensive Ir-based catalysts for an anodic oxygen evolution reaction, their long-term performance is compromised by overoxidation at high current densities. In addressing this challenge, we present a cooperative dual-site strategy for atomic-scale incorporation of high-valent d0-metal cations into RuO2. This synthesis results in uniformly distributed Ru-O-d0metal bonds, effectively reconciling the activity and stability trade-off. Leveraging these effects, our optimized Ta1/RuO2 catalyst demonstrates exceptional performance, with a low overpotential of 164 ± 2 mV and stable operation for 1000 h at 100 mA cm-2. In practical PEMWE systems, Ta1/RuO2 achieves 1.58 V at 2 A cm-2, surpassing the 2026 Department of Energy target, and maintains remarkable stability over 650 h at 500 mA cm-2. This breakthrough offers a highly active and durable PEMWE system suitable for industrial-scale applications.