Abstract
We designed and synthesised an anionic small-molecular photosensitizer (aPSM-Cy3.5) for incorporation into electrostatic antibody targeted (ELART) vesicles, consisting of a protamine-coupled antibody as targeting unit, free protamine and aPSM-Cy3.5. These nanocarriers specifically internalize into different solid tumour cell lines. Upon illumination, the aPSM component initiates the production of reactive oxygen species (ROS). Tumour cells from lung, colorectal and pancreatic cancer with internalized aPSM show decreased growth in colony forming assay. This supports the development of systemically applicable anionic ROS inducers capable of specifically targeting tumour cells.
MeSH terms
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Antibodies* / chemistry
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Antineoplastic Agents* / chemical synthesis
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / pharmacology
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Carbocyanines / chemistry
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Carbocyanines / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Drug Carriers* / chemistry
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Drug Screening Assays, Antitumor
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Humans
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Nanoparticles* / chemistry
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Photochemotherapy
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Photosensitizing Agents* / chemical synthesis
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Photosensitizing Agents* / chemistry
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Photosensitizing Agents* / pharmacology
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Protamines / chemistry
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Reactive Oxygen Species* / metabolism
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Static Electricity
Substances
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Reactive Oxygen Species
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Photosensitizing Agents
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Drug Carriers
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Antineoplastic Agents
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Antibodies
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Protamines
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Carbocyanines