Promoting large multinational academic clinical trials for gastrointestinal cancers in Europe: the ENGIC (European Network for GI Cancers) initiative

ESMO Open. 2025 May;10(5):105055. doi: 10.1016/j.esmoop.2025.105055. Epub 2025 May 6.

Abstract

This paper outlines proposals for the setup of a European Network for Gastro-Intestinal Cancers (ENGIC) initiative, aiming at promoting and fostering strategic academic clinical trials for gastrointestinal cancers in Europe. We discuss the presentation of the network, its main objectives, organization, internal/external processes, operational activities, governance and, finally, priority actions for the future. We propose that this provides a model that could be adopted by researchers working in other disease areas.

Keywords: European research network; clinical trials; gastrointestinal tumours; molecular oncology; precision medicine.

MeSH terms

  • Clinical Trials as Topic* / organization & administration
  • Europe / epidemiology
  • Gastrointestinal Neoplasms* / therapy
  • Humans