Moving towards sequencing-based metabolomics

Trends Genet. 2025 Jul;41(7):554-555. doi: 10.1016/j.tig.2025.04.006. Epub 2025 May 6.

Abstract

Metabolites are chemically heterogeneous and difficult to quantify in easily read formats. Recently, Tan and Fraser demonstrated that metabolites can be readily quantified by pairing aptamer function with DNA sequencing. This reflects a larger trend of sequencing for assessing biomolecule abundances, further leading to sequencing being a universal analytical tool.

Keywords: DNA sequencing; aptamers; high-throughput metabolomics.

Publication types

  • Editorial

MeSH terms

  • Aptamers, Nucleotide / genetics
  • High-Throughput Nucleotide Sequencing* / methods
  • Humans
  • Metabolome* / genetics
  • Metabolomics* / methods
  • Metabolomics* / trends
  • Sequence Analysis, DNA* / methods

Substances

  • Aptamers, Nucleotide