Incidence of bacteremia following Endo-Bronchial Ultrasound (EBUS) Guided Trans-Bronchial Needle Aspiration (TBNA) - A prospective study

Elad Mor; Anat Stern; Moran Szwarcwort; Stav Rakedzon; Anna Solomonov; Eyal Fuchs; Hanna A Dawood; Tzah Feldman; Marina Levi; Aeyal Raz; Yaniv Dotan

doi:10.1016/j.rmed.2025.108149

Incidence of bacteremia following Endo-Bronchial Ultrasound (EBUS) Guided Trans-Bronchial Needle Aspiration (TBNA) - A prospective study

Respir Med. 2025 Jul:243:108149. doi: 10.1016/j.rmed.2025.108149. Epub 2025 May 7.

Authors

Elad Mor¹, Anat Stern², Moran Szwarcwort³, Stav Rakedzon⁴, Anna Solomonov⁴, Eyal Fuchs⁴, Hanna A Dawood⁴, Tzah Feldman⁵, Marina Levi⁶, Aeyal Raz⁷, Yaniv Dotan⁴

Affiliations

¹ Pulmonary Institute, Rambam Health Care Campus, HaAliya HaShniya St 8, Haifa, 3109601, Israel; Ruth and Bruce Rappaport Faculty of Medicine, The Technion - Israel Institute of Technology, Efron St 1, Haifa, Israel. Electronic address: Elad.Mor@ubc.ca.
² Ruth and Bruce Rappaport Faculty of Medicine, The Technion - Israel Institute of Technology, Efron St 1, Haifa, Israel; Infections Disease Institute, Rambam Health Care Campus, Haifa, Israel.
³ Microbiology Laboratory, Rambam Health Care Campus, Haifa, Israel.
⁴ Pulmonary Institute, Rambam Health Care Campus, HaAliya HaShniya St 8, Haifa, 3109601, Israel; Ruth and Bruce Rappaport Faculty of Medicine, The Technion - Israel Institute of Technology, Efron St 1, Haifa, Israel.
⁵ Pathology Institute, Rambam Health Care Campus, Haifa, Israel.
⁶ Pulmonary Institute, Rambam Health Care Campus, HaAliya HaShniya St 8, Haifa, 3109601, Israel.
⁷ Department of Anesthesiology, Rambam Health Care Campus, Haifa, Israel.

PMID: 40345259
DOI: 10.1016/j.rmed.2025.108149

Abstract

Background and objective: The risk of bacteremia following bronchoscopy procedures is well studied but limited data exists on bacteremia following Endo-Bronchial Ultrasound (EBUS) Guided Trans-Bronchial Needle Aspiration (TBNA). This prospective study aimed to assess bacteremia incidence following EBUS-TBNA, compare the findings to other studies made for various bronchoscopy procedures and evaluate the necessity of antibiotic prophylaxis.

Methods: We prospectively collected blood cultures pre- and post-procedure from 100 patients who underwent EBUS-TBNA in a single large center.

Results: The study revealed a 3 % bacteremia following EBUS-TBNA with no correlation between bacteremia and lymph node location or size.

Conclusion: The results align with prior bronchoscopy studies, suggesting bacteremia rates range between 2 % and 7 %, with no clear association with procedure type.

Keywords: Bacteremia; Bronchoscopy; Endobronchial ultrasound; Infection.

MeSH terms

Adult
Aged
Aged, 80 and over
Antibiotic Prophylaxis
Bacteremia* / epidemiology
Bacteremia* / etiology
Bacteremia* / prevention & control
Bronchoscopy* / adverse effects
Bronchoscopy* / methods
Endoscopic Ultrasound-Guided Fine Needle Aspiration* / adverse effects
Endoscopic Ultrasound-Guided Fine Needle Aspiration* / methods
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies