Genomics of Suicidal Behaviors: What Can We Learn from Polygenic Scores?

Abstract

Substantial evidence supports the role of genetic factors in suicide behaviors (SBs). The most recent and powered genome-wide association studies identified significant loci for suicide, suicide attempts, and suicide ideation. Nonetheless, more research is needed to fully understand its impact. A novel approach considering the genetic complexity of SBs is polygenic scores that, in conjunction with individual and environmental factors, may have promising results to inform suicide risk stratification. Communicating this information to patients and the open population may have ethical implications that need to be considered to avoid iatrogenic effects.

Keywords: Genetic; Genomic; Individual and environmental factors; Polygenic score; Suicide; Suicide attempt; Suicide behaviors; Suicide ideation.