Dyskinesia-Hyperpyrexia Syndrome in Parkinson's Disease May Benefit from GPi Deep Brain Stimulation: A Case Report

Tremor Other Hyperkinet Mov (N Y). 2025 May 7:15:20. doi: 10.5334/tohm.912. eCollection 2025.

Abstract

Background: Dyskinesia-hyperpyrexia syndrome (DHS) is a rare but life-threatening complication in Parkinson's disease (PD). Its prevention and treatment are clinical challenges.

Case report: We herein present a case of a female PD patient who experienced recurrent episodes of DHS and levodopa-induced dyskinesia. The complications were alleviated after bilateral globus pallidus internus (GPi) deep brain stimulation (DBS).

Discussion: Our report provides evidence that GPi DBS may reduce the susceptibility to DHS. More evidences are warranted to validate this hypothesis.

Keywords: Deep brain stimulation; Dyskinesia; Dyskinesia-hyperpyrexia syndrome; Globus pallidus internus; Parkinson’s disease.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antiparkinson Agents / adverse effects
  • Deep Brain Stimulation* / methods
  • Dyskinesia, Drug-Induced* / etiology
  • Dyskinesia, Drug-Induced* / therapy
  • Female
  • Fever* / etiology
  • Fever* / therapy
  • Globus Pallidus* / physiopathology
  • Humans
  • Levodopa / adverse effects
  • Parkinson Disease* / complications
  • Parkinson Disease* / therapy
  • Syndrome

Substances

  • Antiparkinson Agents
  • Levodopa