Genomic Modeling of an Outbreak of Multidrug-Resistant Shigella sonnei, California, USA, 2023-2024

Emerg Infect Dis. 2025 May;31(13):98-102. doi: 10.3201/eid3113.241307.

Abstract

We report the detection of a Shigella sonnei outbreak from a small investigation in the San Francisco Bay area, California, USA, in 2024. By combining outbreak investigation with genomic sequencing, we show the utility of phylodynamics to aid outbreak investigations of bacterial pathogens by state or local public health departments.

Keywords: California; Shigella sonnei; United States; antimicrobial resistance; bacteria; epidemiology; multidrug resistance; outbreak; phylodynamic modelling.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • California / epidemiology
  • Disease Outbreaks*
  • Drug Resistance, Multiple, Bacterial* / genetics
  • Dysentery, Bacillary* / epidemiology
  • Dysentery, Bacillary* / history
  • Dysentery, Bacillary* / microbiology
  • Genome, Bacterial
  • Genomics
  • Humans
  • Phylogeny
  • Shigella sonnei* / classification
  • Shigella sonnei* / drug effects
  • Shigella sonnei* / genetics
  • Shigella sonnei* / isolation & purification

Substances

  • Anti-Bacterial Agents