The role of point-of-care ultrasonography in central venous catheter insertion: A randomized controlled trial of safety and cost-effectiveness

Ahmed Beniamen; Ahmed Mosallem; Hossam Tharwat Ali; Hanaa A Nofal; Essamedin M Negm

doi:10.1016/j.medine.2025.502221

The role of point-of-care ultrasonography in central venous catheter insertion: A randomized controlled trial of safety and cost-effectiveness

Med Intensiva (Engl Ed). 2025 May 14:502221. doi: 10.1016/j.medine.2025.502221. Online ahead of print.

Authors

Ahmed Beniamen¹, Ahmed Mosallem¹, Hossam Tharwat Ali², Hanaa A Nofal³, Essamedin M Negm¹

Affiliations

¹ Anesthesia, Intensive Care and Pain Management, Zagazig University Hospital, Egypt.
² Qena Faculty of Medicine, South Valley University, Qena 83621, Egypt. Electronic address: hossamtharwatali@gmail.com.
³ Community, Environmental Occupational Medicine Department, Faculty of Medicine, Zagazig University, Egypt.

PMID: 40374442
DOI: 10.1016/j.medine.2025.502221

Abstract

Objective: The objective of the study was to compare landmark-based and ultrasound-guided techniques of central venous catheter insertion (CVC).

Design: Randomized controlled trial (2021-2023).

Setting: Zagazig University Hospitals (ZUH), a tertiary care center.

Patients: Adult patients in whom CVC insertion is indicated.

Main variables of interest: Demographic and clinical peri-procedural data, the safety of the technique, time of performance, and cost-effectiveness were compared.

Results: Patient ages ranged from 17 to 80 years with 56% being males. Urgent indications were found in around 22% without significant differences between groups. Regarding the time of performance, the ultrasound-guided method had slightly but significantly less time of performance (25.7 ± 4.3; range: 18-33) compared to the blind technique (26.9 ± 7.4; range: 15-45) (P-value < 0.001) with a higher but non-significant number of patients without complications (64% vs 52%; P-value = 0.2). Failure to insert the CVC into the IJV occurred in 12 patients (12%) with the blind technique and in eight patients (8%) with the ultrasound-guided technique (P-value = 0.04). Carotid artery puncture with neck hematoma occurred in only 8 (8%) patients with the blind technique (P-value = 0.04). Excess cost was consumed in only 36 patients (36%) in the blind technique group (P-value = 0.001).

Conclusion: Point-of-care ultrasonography bundle for CVC insertion is considered superior to, safer, and more cost-effective than the blind technique.

Keywords: Catéter venoso central; Central venous catheter; Ensayo; Internal jugular vein; Trial; Ultrasonido; Ultrasonografía; Ultrasonography; Ultrasound; Vena yugular interna.