Transthyretin Gene Silencing in Amyloid Transthyretin Cardiomyopathy: A Novel Treatment Delivers New Dilemmas

J Am Coll Cardiol. 2025 Apr 29:S0735-1097(25)06219-9. doi: 10.1016/j.jacc.2025.04.015. Online ahead of print.

¹ Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address: Amrut.Ambardekar@cuanschutz.edu.
² Cardiovascular Imaging Program, Cardiovascular Division, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address: https://twitter.com/sarahcud.

No abstract available

Keywords: HELIOS-B trial; RNA interference; heart failure; transthyretin cardiac amyloidosis; vutrisiran.

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