CT, I-123-Ioflupane SPECT, and Integrated FDG PET-MRI of a Patient With Fahr Disease

Clin Nucl Med. 2025 Jul 1;50(7):660-663. doi: 10.1097/RLU.0000000000005777. Epub 2025 May 19.

Abstract

Fahr disease is a rare neurodegenerative syndrome characterized by abnormal symmetric calcium deposition in the white matter, cerebral cortex, deep gray, and cerebellar nuclei. The characteristic CT pattern is well known, but descriptions of molecular imaging in Fahr disease remain sparse. We present the characteristic imaging patterns of Fahr disease by CT, I-123-Ioflupane SPECT, and integrated FDG PET/MRI in a single patient.

Keywords: 123I–Ioflupane; Fahr disease; PET/MRI; brain SPECT; dementia with Lewy bodies; fluorodeoxyglucose.

Publication types

  • Case Reports

MeSH terms

  • Basal Ganglia Diseases* / diagnostic imaging
  • Calcinosis
  • Fluorodeoxyglucose F18*
  • Humans
  • Iodine Radioisotopes
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Multimodal Imaging*
  • Neurodegenerative Diseases* / diagnostic imaging
  • Nortropanes*
  • Positron-Emission Tomography*
  • Tomography, Emission-Computed, Single-Photon*
  • Tomography, X-Ray Computed*

Substances

  • Fluorodeoxyglucose F18
  • Iodine Radioisotopes
  • ioflupane
  • Nortropanes

Supplementary concepts

  • Fahr's disease