Poly(N-acyliminophosphoranes): main chain functionalized poly(ylides) with pH-dependent degradation

Chem Commun (Camb). 2025 Jun 12;61(49):8903-8906. doi: 10.1039/d5cc01640a.

Abstract

Zwitterionic polymers have gained attention for various applications but are typically based on non-degradable polyolefin backbones. Here, we introduce an Fe(II)-catalyzed step-growth polymerization that enables N-acyliminophosphorane formation, incorporating ylides directly into the polymer main chain. This design imparts pH-responsive degradability in aqueous environments, and opens opportunities for stimuli-responsive polymer systems.