Purpose: To investigate the effect and safety of fibrin glue-assisted pre-treated lyophilized human amniotic membrane (LhAM) for retinal detachment (RD) caused by inferior retinal breaks (IRBs).
Methods: The retinal breaks were sealed with intraocular photocoagulation after the retina was reattached. The LhAM grafts were soaked in hypertonic glucose solution, followed by immersion in fibrin glue A (pre-treatment), then dipped into the perfluorocarbon liquid (PFCL) and used to cover the breaks, or implanted under the breaks. Finally, the edge of the breaks and grafts were covered with fibrin glue B.
Results: Retinal reattachment was successful in all cases, and the median best corrected visual acuity improved from 20/20020/130 (Snellen) to 20/30 (Snellen) at the last visit. LhAM graft was displaced by fibrin contraction in one case after surgery, while the fibrin glue and grafts were stabilized in the other sixfive cases. A little fibrin glue residue was detected in the macula area of 2 cases. One patient developed mild uveitis at 5 months after surgery but recovered after treatment.
Conclusions: The fibrin glue-assisted pre-treated LhAM can achieve anatomical retinal reattachment for RD caused by IRBs. Besides, this method can avoid intraocular tamponade of silicone oil and does not require post-operative position.
Keywords: Fibrin glue; inferior retinal breaks; lyophilized human amniotic membrane; retinal detachment.
Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc.