The Role of AP2/ERF Transcription Factors in Plant Responses to Biotic Stress

Int J Mol Sci. 2025 May 21;26(10):4921. doi: 10.3390/ijms26104921.

Abstract

The APETALA2/ethylene response factor (AP2/ERF) family of transcription factors (TFs) is one of the largest and most important TF families in plants. This family plays a crucial role in regulating growth, development, and responses to both biotic and abiotic stresses. This study provides a comprehensive overview of the structure, classification, and distribution of AP2/ERF TFs in various plant species, with particular emphasis on their roles in responses to biotic stress. These findings provide valuable insights for future research on AP2/ERF TFs and their potential applications in crop improvement through molecular breeding.

Keywords: AP2/ERF; biotic stress; molecular breeding; regulation expression; transcription factors.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation, Plant
  • Plant Proteins* / genetics
  • Plant Proteins* / metabolism
  • Plants* / genetics
  • Plants* / metabolism
  • Stress, Physiological* / genetics
  • Transcription Factor AP-2 / genetics
  • Transcription Factor AP-2 / metabolism
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism

Substances

  • Plant Proteins
  • Transcription Factors
  • Transcription Factor AP-2