Epigenetic regulation of B cell response in autoimmune diseases

Abstract

The maintenance of peripheral tolerance depends on various regulatory mechanisms. Thus, the breakdown of self-tolerance leads to the development of autoimmunity. Although the pathogenesis of autoimmune diseases is complex, they are primarily antibody mediated. Notably, autoreactive antibodies are detectable in ∼70% of patients with rheumatoid arthritis and have pathogenic effects. Hence, it is important to investigate the molecular mechanisms underlying B cell response in autoimmune diseases. Recent studies have shed light on the alterations in epigenetic modifications that accompany the development of autoimmune diseases. In this review, we will discuss the recent advances in this field, which may provide precise clues for the diagnosis and therapies for patients with autoimmune disorders.