New diagnostic and staging framework applied to established PD in the BioFIND cohort

Marco J Russo; Un Jung Kang; BioFIND Study

doi:10.1038/s41531-025-00992-3

New diagnostic and staging framework applied to established PD in the BioFIND cohort

NPJ Parkinsons Dis. 2025 Jun 4;11(1):151. doi: 10.1038/s41531-025-00992-3.

Authors

Marco J Russo¹, Un Jung Kang²; BioFIND Study

Collaborators

BioFIND Study:
Roy N Alcalay, Amy Amara, Vanessa Arnedo, Samuel Frank, Mark Frasier, Jennifer G Goldman, Katrina Gwinn, Claire Henchcliffe, Penelope Hogarth, Anna Naito, Alyssa N Reimer, Marie-Helene Saint-Hilaire, Christine Swanson-Fischer, Margaret Sutherland, Paul Tuite, Tao Xie

Affiliations

¹ Movement Disorders Division, Department of Neurology, Rutgers University, Robert Wood Johnson Medical School, New Brunswick, NJ, USA. marco.russo@rutgers.edu.
² The Marlene and Paolo Fresco Institute for Parkinson's & Movement Disorders, Department of Neurology, Department of Neuroscience and Physiology, Neuroscience Institute, The Parekh Center for Interdisciplinary Neurology, NYU Grossman School of Medicine, New York, NY, USA.

Abstract

The proposed Neuronal α-Synuclein Disease Integrated Staging System (NSD-ISS) was recently applied to early Parkinson's disease (PD) cohorts. We applied this research framework to the BioFIND study cohort, which includes more moderately advanced PD participants with clinically established PD. Disease durations within each ISS stage were highly variable. Cognitive and non-motor anchors had little weight in determining staging. The analysis highlights strengths and limitations of NSD-ISS to guide further refinement of an integrated staging system.

Abstract

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