Spaceflight redefines ageing-associated microbiota

Yuan Sun; Sai Liu; Long Chen; Zheng Zhou; Mengyu Ma; Jinran Li; Yi Lu; Yiting Shi; Tingting Yao; Ruizhi Feng; Qiulun Lu; Fatimah Qassadi; Philip M Williams; Tanya M Monaghan; Guangji Wang; Zheying Zhu; Xinuo Li

doi:10.1002/imt2.70023

Spaceflight redefines ageing-associated microbiota

Imeta. 2025 Mar 28;4(3):e70023. doi: 10.1002/imt2.70023. eCollection 2025 Jun.

Authors

Yuan Sun¹, Sai Liu¹, Long Chen¹, Zheng Zhou², Mengyu Ma¹, Jinran Li¹, Yi Lu¹, Yiting Shi¹, Tingting Yao¹, Ruizhi Feng³, Qiulun Lu¹, Fatimah Qassadi⁴, Philip M Williams⁴, Tanya M Monaghan^{5

6}, Guangji Wang¹, Zheying Zhu⁴, Xinuo Li¹

Affiliations

¹ State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing China.
² Department of Computer Science RWTH Aachen University Aachen Germany.
³ State Key Laboratory of Reproduction Medicine and Offspring Health Nanjing Medical University Nanjing China.
⁴ School of Pharmacy The University of Nottingham Nottingham UK.
⁵ NIHR Nottingham Biomedical Research Centre University of Nottingham Nottingham UK.
⁶ Nottingham Digestive Disease Centre, School of Medicine University of Nottingham Nottingham UK.

Abstract

Spaceflight reshapes microbiota and immune function, mitigating some ageing effects while accelerating immune aging, revealing crucial insights for astronaut health and longevity in space missions.

Publication types

Letter