The electrophilic trifluoromethylselenolation cyclizations of propargylic amides are disclosed. The transformations undergo the 6-endo-dig and 5-exo-dig cyclizations to synthesize SeCF3-substituted oxazines and oxazolines, respectively, which are induced by N-trifluoromethylselenophthalimide. This protocol is suitable for late-stage applications of complex natural products and drug molecules.