Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation

Affiliations

• ¹ Department of Pediatric Endocrinology, Reference Center for Rare Pituitary Diseases (CRMR-HYPO), Angers University Hospital, Angers, France.
• ² Paris-Saclay University, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Department of Endocrinology and Reproductive Diseases, Reference Center for Rare Pituitary Diseases (CRMR-HYPO), Paris 94275, France; INSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France.
• ³ Department of Endocrinology, Diabetology and Nutrition, Reference Center for Rare Pituitary Diseases HYPO, Angers University Hospital, Angers, France.
• ⁴ INSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France.
• ⁵ INSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France; Department of Endocrinology, Diabetology and Nutrition, Reference Center for Rare Pituitary Diseases HYPO, Angers University Hospital, Angers, France; Paris-Saclay University, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Department of Molecular Genetics, Pharmacogenomics, and Hormonology, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Paris, France.
• ⁶ Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
• ⁷ Paris-Saclay University, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Department of Endocrinology and Reproductive Diseases, Reference Center for Rare Pituitary Diseases (CRMR-HYPO), Paris 94275, France; INSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France. Electronic address: luigi.maione@aphp.fr.