Developing a novel reference region for [18F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies

Developing a novel reference region for [¹⁸F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies

Eur J Nucl Med Mol Imaging. 2025 Jun 10. doi: 10.1007/s00259-025-07396-8. Online ahead of print.

Lukas Frontzkowski^#^{1

2}, Johannes Gnörich^#³, Mattes Gross^#^{4

3}, Amir Dehsarvi⁴, Sebastian N Roemer-Cassiano^{4

5}, Carla Palleis^{5

6

7}, Sabrina Katzdobler⁵, Anna Dewenter⁴, Anna Steward⁴, Davina Biel⁴, Fabian Hirsch⁴, Zeyu Zhu⁴, Johannes Levin^{5

6

7}, Andrew W Stephens⁸, Andre Müller⁸, Norman Koglin⁸, Gérard N Bischof⁸, Gabor G Kovacs^{9

10}, Günter U Höglinger^{5

6

7}, Matthias Brendel^#^{3

6

7}, Nicolai Franzmeier^#^{4

6

11}

¹ Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Straße 17, Munich, 81377, Germany. lukas.frontzkowski@med.uni-muenchen.de.
² Department of Nuclear Medicine, LMU University Hospital, Marchioninistraße 15, Munich, 81377, Germany. lukas.frontzkowski@med.uni-muenchen.de.
³ Department of Nuclear Medicine, LMU University Hospital, Marchioninistraße 15, Munich, 81377, Germany.
⁴ Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Feodor-Lynen-Straße 17, Munich, 81377, Germany.
⁵ Department of Neurology, LMU University Hospital, Munich, Germany.
⁶ Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
⁷ German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
⁸ Life Molecular Imaging, GmbH, Berlin, Germany.
⁹ Tanz Centre for Research in Neurodegenerative Disease (CRND), Toronto, Canada.
¹⁰ Laboratory Medicine Program and Krembil Brain Institute, University Health Network, Toronto, Canada.
¹¹ The Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal and Gothenburg, Sweden.

^# Contributed equally.

No abstract available

Keywords: Four-repeat tauopathies; Progressive supranuclear palsy; Reference region; Tau; [18F]PI-2620.