A plant Lysin Motif Receptor-Like Kinase plays an ancestral function in mycorrhiza

Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2426063122. doi: 10.1073/pnas.2426063122. Epub 2025 Jun 11.

Abstract

Arbuscular mycorrhiza (AM) with soilborne Glomeromycota fungi was pivotal in the conquest of land by plants almost half a billion years ago. In flowering plants, it is hypothesized that AM is initiated by the perception of AM fungi-derived chito- and lipochito-oligosaccharides (COs/LCOs) in the host via Lysin Motif Receptor-Like Kinases (LysM-RLKs). However, it remains uncertain whether plant perception of these molecules is a prerequisite for AM establishment and for its origin. Here, we made use of the reduced LysM-RLK complement present in the liverwort Marchantia paleacea to assess the conservation of the role played by this class of receptors during AM and in CO/LCO perception. Our reverse genetic approach demonstrates the critical function of a single LysM-RLK, MpaLYKa, in AM formation, thereby supporting an ancestral function for this receptor in symbiosis. Binding studies, cytosolic calcium variation recordings and genome-wide transcriptomics indicate that another LysM-RLK of M. paleacea, MpaLYR, is also required for triggering a response to COs and tested LCOs, despite being dispensable for AM formation. Collectively, our results demonstrate that the perception of symbionts by LysM-RLK is an ancestral feature in land plants, and suggest the existence of yet-uncharacterized AM fungi signals.

Keywords: LysM-RLKs; Marchantia paleacea; arbuscular mycorrhiza.

MeSH terms

  • Glomeromycota
  • Marchantia* / enzymology
  • Marchantia* / genetics
  • Marchantia* / microbiology
  • Mycorrhizae* / genetics
  • Mycorrhizae* / metabolism
  • Mycorrhizae* / physiology
  • Phylogeny
  • Plant Proteins* / genetics
  • Plant Proteins* / metabolism
  • Protein Kinases* / genetics
  • Protein Kinases* / metabolism
  • Symbiosis

Substances

  • Plant Proteins
  • Protein Kinases