[Correlation between serum uric acid-to-high-density lipoprotein cholesterol ratio and risk of all-cause death or cardiovascular disease death in urban and rural elderly of Beijing]

Abstract

Objective: To analyze the correlation between serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) and risk of all-cause death or cardiovascular disease (CVD) death among urban and rural elderly in Beijing. Methods: Based on the Beijing Healthy Aging Cohort Study, 9 022 participants with complete baseline data were enrolled, and their survival and death outcomes were followed up. Multivariable Cox proportional hazard regression model were used to analyze the associations between the UHR level and the risks of all-cause mortality and CVD mortality. Results: As of March 31, 2021, the median follow-up time M(Q₁,Q₃) was 6.18 (5.36, 6.75) years. There were 1 166 all-deaths, with a death density of 19.26 per 1 000 person-years, and 562 CVD deaths, with a death density of 9.28 per 1 000 person-years. After adjusting sociodemographic characteristics and lifestyle factors, multivariable Cox proportional hazard regression model showed that the risk of all-cause mortality increased by 3% (HR=1.03, 95%CI: 1.02-1.04) and the risk of CVD mortality increased by 4% (HR=1.04, 95%CI: 1.02-1.06) for every 1% increase in UHR. Compared with the T₁ group of UHR tertiles, the T₃ group had a 42% increase in the risk of all-cause death (HR=1.42, 95%CI: 1.22-1.66) and a 53% increase in the risk of CVD death (HR=1.53, 95%CI: 1.21-1.94). Conclusions: The UHR level is significantly associated with the risks of all-cause mortality and CVD mortality among urban and rural older adults in Beijing. The UHR level may be one of the potential predictors of death risk in community-dwelling older adults.