Meningitis as an Attack Phenotype of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Albert Aboseif; Nee Na Kim; Gabriela Bou; Nabeela Nathoo; Yong Guo; Julie Pique; Anne Kerbrat; Bertrand Audoin; Sarah Demortiere; Bertrand Bourre; Jonathan Ciron; John J Chen; Laura Cacciaguerra; Michel Toledano; Amy May Lin Quek; Grace Gombolay; Romain Marignier; Yael Hacohen; Eoin P Flanagan

doi:10.1001/jamaneurol.2025.1774

Meningitis as an Attack Phenotype of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

JAMA Neurol. 2025 Jun 16. doi: 10.1001/jamaneurol.2025.1774. Online ahead of print.

Authors

Albert Aboseif¹, Nee Na Kim^{2

3}, Gabriela Bou⁴, Nabeela Nathoo¹, Yong Guo¹, Julie Pique^{5

6}, Anne Kerbrat⁷, Bertrand Audoin⁸, Sarah Demortiere⁸, Bertrand Bourre⁹, Jonathan Ciron¹⁰, John J Chen^{1

11}, Laura Cacciaguerra^{1

12}, Michel Toledano¹, Amy May Lin Quek¹³, Grace Gombolay⁴, Romain Marignier^{5

6}, Yael Hacohen^{2

3}, Eoin P Flanagan^{1

12}

Affiliations

¹ Center for Multiple Sclerosis and Autoimmune Neurology, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota.
² Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom.
³ Great Ormond Street Hospital, University College London, London, United Kingdom.
⁴ Department of Neurology, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia.
⁵ Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.
⁶ Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France.
⁷ Department of Neurology, University Hospital of Rennes, Rennes, France.
⁸ Department of Neurology, University Hospital of Marseille, Marseille, France.
⁹ Department of Neurology, Université de Rouen Normandie, Rouen, France.
¹⁰ Department of Neurology, University Hospital of Toulouse, Toulouse, France.
¹¹ Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota.
¹² Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota.
¹³ Division of Neurology, Department of Medicine, National University Health System, Singapore.

PMID: 40522676
DOI: 10.1001/jamaneurol.2025.1774

No abstract available

Plain language summary

This international multicenter study seeks to determine the frequency and characteristics of meningitis in myelin oligodendrocyte glycoprotein antibody (MOGAD)–associated disease and highlight its pathology.