Carbapenem-resistant Enterobacterales peri-rectal colonization prevalence on admission to two intensive care units in an academic hospital in India

Armaghan-E-Rehman Mansoor; Fabia Edathadathil; Devendhu Suresh; Yathu Krishna; Anu George; Jacaranda van Rheenen; Ige A George; Jennie H Kwon; Emily E Petersen; Matthew Westercamp; Anil Kumar; Sudheer O Vayoth; Margaret A Olsen; Surbhi Leekha; Sanjeev K Singh; David K Warren; Sumanth Gandra

doi:10.1017/ash.2025.10036

Carbapenem-resistant Enterobacterales peri-rectal colonization prevalence on admission to two intensive care units in an academic hospital in India

Antimicrob Steward Healthc Epidemiol. 2025 May 30;5(1):e120. doi: 10.1017/ash.2025.10036. eCollection 2025.

Authors

Armaghan-E-Rehman Mansoor¹, Fabia Edathadathil², Devendhu Suresh², Yathu Krishna², Anu George², Jacaranda van Rheenen³, Ige A George³, Jennie H Kwon³, Emily E Petersen⁴, Matthew Westercamp⁴, Anil Kumar², Sudheer O Vayoth², Margaret A Olsen³, Surbhi Leekha⁵, Sanjeev K Singh^#², David K Warren^#³, Sumanth Gandra^#³

Affiliations

¹ Division of Infectious Diseases, Department of Internal Medicine, University of Kentucky, Kentucky, USA.
² Amrita Institute of Medical Sciences, Kochi, KL, India.
³ Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, USA.
⁴ Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA.
⁵ Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.

^# Contributed equally.

Abstract

This study from a South Indian tertiary care hospital found a 41% peri-rectal Carbapenem-resistant Enterobacterales colonization prevalence at intensive care unit admission, with New Delhi metallo-β-lactamase as the predominant carbapenemase. It underscores the need for contextually appropriate, cost-effective infection prevention strategies to mitigate the spread of resistant organisms in Indian healthcare settings.