New α-Pyrones From Endophytic Fusarium Sp. L46 Isolated From Dioscorea opposita

Ruo-Dan Tian; Ying-Fei Zhao; Fei-Fan Wang; Song-Jie Zhan; Chun-Nan Wen; Miao Liu; Bing-Ji Ma

doi:10.1002/cbdv.202500223

New α-Pyrones From Endophytic Fusarium Sp. L46 Isolated From Dioscorea opposita

Chem Biodivers. 2025 Jun 18:e00223. doi: 10.1002/cbdv.202500223. Online ahead of print.

Authors

Ruo-Dan Tian¹, Ying-Fei Zhao¹, Fei-Fan Wang¹, Song-Jie Zhan¹, Chun-Nan Wen^{1

2}, Miao Liu^{1

2}, Bing-Ji Ma^{1

2}

Affiliations

¹ College of Agronomy, Henan Agricultural University, Zhengzhou, P. R. China.
² Zhengzhou Key Laboratory of Germplasm Resources Innovation and Metabolic Engineering of Traditional Chinese Medicine, Henan Agricultural University, Zhengzhou, P. R. China.

PMID: 40531800
DOI: 10.1002/cbdv.202500223

Abstract

Fusarilactones D and E (1 and 2), two new α-pyrone derivatives, and four known compounds, namely, phomapyrone C (3), fusarester C (4), neovasifuranone B (5), and neovasifuranone A (6), were isolated from Fusarium sp. L46, an endophytic fungus isolated from Dioscorea opposita leaves. Their structures were determined using 1D and 2D NMR spectra, HRESIMS, and optical rotation measurements. Compounds 3-5 were assessed for their inhibitory activity on pancreatic lipase.

Keywords: endophytic fungus; genus Fusarium; pancreatic lipase inhibitory activity; α‐pyrone.