Local injection of platelet-rich plasma is effective for non-healing hand wounds

Jiangqiang Chen; Zuhui Chen; Weibin Zheng; Xiangqian Shen

doi:10.62347/CRQK7620

Local injection of platelet-rich plasma is effective for non-healing hand wounds

Am J Transl Res. 2025 May 15;17(5):3505-3513. doi: 10.62347/CRQK7620. eCollection 2025.

Authors

Jiangqiang Chen¹, Zuhui Chen¹, Weibin Zheng¹, Xiangqian Shen²

Affiliations

¹ Department of Plastic Surgery, Tiantai County People's Hospital Tiantai County, Taizhou 317200, Zhejiang, China.
² Department of Plastic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310003, Zhejiang, China.

Abstract

Objective: To evaluate the clinical efficacy of local platelet-rich plasma (PRP) injections in treating non-healing hand wounds.

Methods: Data of 80 patients with non-healing hand wounds were retrospectively selected for this study. Among them, 48 patients in the research group received local PRP injections, while 32 patients in the control group were treated with conventional dressing changes. The outcomes assessed included treatment efficacy, safety, frequency of dressing change, wound healing time, duration of hospitalization, treatment costs, wound healing rate, wound infection rate, Vancouver Scar Scale (VSS) scores, Bates-Jensen Wound Assessment Tool (BWAT) scores, Visual Analogue Scale (VAS) scores, serum wound growth factors, and patient satisfaction with wound appearance.

Results: The research group demonstrated significantly superior outcomes compared to the control group, including higher overall treatment efficacy and wound healing rates. Furthermore, the research group exhibited a significantly lower incidence of adverse events, reduced frequency of dressing changes, shorter wound healing time, reduced hospitalization duration, lower treatment costs, and a lower infection rate. Post-treatment assessments revealed significantly lower VSS, BWAT, and VAS scores in the research group. Additionally, the upregulation of serum wound growth factors was more pronounced in the research group following treatment.

Conclusions: Local PRP injection demonstrates clear efficacy in the management of non-healing hand wounds.

Keywords: Platelet-rich plasma; clinical efficacy; local injection; non-healing hand wounds.