Misinformation about COVID and the vaccine are rampant in Guatemala. Insights are needed from community leaders regarding public perceptions of the pandemic to inform effective interventions. Thus, 210 lay midwives participated in 11 focus groups. Participants shared the knowledge, practices, and attitudes of their families and communities about COVID-19 and the vaccine. Five themes emerged. Myths about the vaccine abound. Guatemalans use traditional remedies to treat COVID, have faith in God to cure them, and mistrust hospital care. The virus impacted cities more than rural areas. Integrating cultural viewpoints with modern information would build trust among Guatemalans regarding COVID-19.