Neuroprognostication and Ethical Considerations in Traumatic Brain Injury

Neurosurg Clin N Am. 2025 Jul;36(3):451-457. doi: 10.1016/j.nec.2025.03.011. Epub 2025 May 8.

Abstract

Neuroprognostication is the prediction of patient neurorehabilitation and neurorecovery and can be challenging for severe traumatic brain injury patients due to limited objective data. Prognostic models can be utilized to aid in prognosis, though current models tend to emphasize mortality and updated models are needed. Emerging technologies advanced imaging, biomarkers, and EEG may help provide additional tools for prognosis. Use of decision aids to guide family discussions can help surrogate decision-makers optimize goals of care.

Keywords: Decision aid; Disability; Neuroprognosis; Recovery; Withdrawal of life-supporting therapy.

Publication types

  • Review

MeSH terms

  • Brain Injuries, Traumatic* / diagnosis
  • Brain Injuries, Traumatic* / physiopathology
  • Electroencephalography
  • Humans
  • Neurological Rehabilitation* / ethics
  • Prognosis