Parkinson's disease (PD) is a chronic progressive neurological degenerative disease caused by the degeneration of dopaminergic neurons in the substantia nigra. α-synuclein (α-Syn) misfolding and aggregation is the crucial pathogenesis of PD, and is closely related to the other pathogenesis, such as brain-gut axis dysfunction, mitochondrial dysfunction, oxidative stress, neuroinflammation, iron and lipid metabolic disorders, and autophagy lysosomal dysfunction. Acupuncture plays a neuroprotective role by attenuating neuroinflammation, regulating brain-gut axis, repairing ubiquitin-proteasome system and autophagy lysosomal system, and modulating signaling pathways, so as to inhibit α-Syn abnormal folding and aggregation. This article reviews the effect of α-Syn in the pathogenesis of PD and acupuncture treatment, so as to provide the valuable guidance for clinical treatment.
帕金森病（PD）是一种由黑质多巴胺能神经元变性引起的慢性进行性神经系统退行性疾病。α-突触核蛋白（α-Syn）错误折叠和聚集是PD的重要发病机制，并且与PD其他发病机制密切相关，如脑肠轴功能障碍、线粒体功能障碍、氧化应激、神经炎性反应、铁和脂质代谢紊乱、自噬-溶酶体功能障碍等。针刺可通过改善神经炎性反应，调控脑肠轴，修复泛素-蛋白酶体系统和自噬-溶酶体系统，调控信号通路等途径抑制α-Syn异常折叠和聚集从而发挥神经保护作用。本文对α-Syn在PD发病中的机制和在针刺治疗中的作用进行归纳整理，以期为临床治疗提供有价值的指导。.
Keywords: Acupuncture; Parkinson’s disease; Research progress; α-synuclein.