MRI for biology-guided radiation therapy: Are we there yet? A summary of the 2024 ISMRM member-initiated session

Sirisha Tadimalla; Jie Deng; Peter B Barker; Hyunsuk Shim; Stefan Reinsberg; Chenyang Liu; Jing Cai; Jonathan Goodwin; Leith Rankine; Yu-Feng Wang; Petra van Houdt; Ralph P Mason; Zhaoyang Fan

doi:10.1002/mrm.30616

MRI for biology-guided radiation therapy: Are we there yet? A summary of the 2024 ISMRM member-initiated session

Magn Reson Med. 2025 Jun 24. doi: 10.1002/mrm.30616. Online ahead of print.

Authors

Sirisha Tadimalla¹, Jie Deng², Peter B Barker^{3

4}, Hyunsuk Shim^{4

5}, Stefan Reinsberg⁶, Chenyang Liu⁷, Jing Cai⁷, Jonathan Goodwin^{8

9}, Leith Rankine¹⁰, Yu-Feng Wang¹, Petra van Houdt¹¹, Ralph P Mason¹², Zhaoyang Fan¹³

Affiliations

¹ Institute of Medical Physics, The University of Sydney, Sydney, New South Wales, Australia.
² Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
³ The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁴ Kennedy Krieger Institute, Baltimore, Maryland, USA.
⁵ Department of Radiation Oncology, Emory University, Atlanta, Georgia, USA.
⁶ Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada.
⁷ Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, China.
⁸ Radiation Oncology Department, Calvary Mater Newcastle, Newcastle, New South Wales, Australia.
⁹ School of Information and Physical Sciences, College of Engineering, Science and Environment, The University of Newcastle, Newcastle, New South Wales, Australia.
¹⁰ Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina, USA.
¹¹ Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
¹² Prognostic Imaging Research Laboratory, Department of Radiology, UT Southwestern Medical Center, Dallas, Texas, USA.
¹³ Departments of Radiology and Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

PMID: 40554724
DOI: 10.1002/mrm.30616

Abstract

At the 2024 ISMRM Annual Meeting in Singapore, a member-initiated session on MRI for biology-guided radiation therapy (RT), endorsed by the ISMRM MR in RT Study Group, was successfully organized. The session convened a diverse group of global experts in quantitative MRI for RT, who presented the latest research on the technical development and clinical translation of various quantitative MRI techniques for biology-guided RT planning and delivery. The session highlighted clinical needs and a variety of MRI techniques, including MR spectroscopic imaging, oxygen-enhanced MRI, four-dimensional MR fingerprinting, dynamic contrast-enhanced MRI, and ¹²⁹Xe MRI. Additionally, technical aspects and challenges for clinical translation of quantitative MRI into biology-guided RT were presented, both in the context of RT planning and adaptation. This article summarizes the progress made in this emerging field, identifies key challenges that need to be addressed, and outlines areas for future research. These insights are crucial for the integration of quantitative MRI techniques into RT clinical practice, ultimately aiming to improve patient outcomes through more personalized RT approaches.

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