Bone Grafting with Albumin-Impregnated Bone Allograft After Odontogenic Cyst Removal

Anna Rangics; Gábor Dénes Répássy; Dóra Hargas; Csaba Dobó-Nagy; Szabolcs Gyulai-Gaál; András Molnár; László Simonffy

doi:10.3390/jcm14124173

Bone Grafting with Albumin-Impregnated Bone Allograft After Odontogenic Cyst Removal

J Clin Med. 2025 Jun 12;14(12):4173. doi: 10.3390/jcm14124173.

Authors

Anna Rangics¹, Gábor Dénes Répássy², Dóra Hargas³, Csaba Dobó-Nagy⁴, Szabolcs Gyulai-Gaál¹, András Molnár⁵, László Simonffy¹

Affiliations

¹ Department of Dentoalveolar Surgery, Dental Training Centre, Faculty of Dentistry, Semmelweis University, 1085 Budapest, Hungary.
² Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Szigony u. 36, 1083 Budapest, Hungary.
³ Faculty of Medicine, Semmelweis University, Üllői út 26, 1085 Budapest, Hungary.
⁴ Department of Oral Diagnostics, Faculty of Dentistry, Semmelweis University, 1085 Budapest, Hungary.
⁵ Opera Clinic, Protone Audio Kft, Lázár u. 4, 1065 Budapest, Hungary.

Abstract

Background: Odontogenic cysts can damage the surrounding bone tissue as they grow, making it essential to implement effective regenerative strategies tailored to each patient. Personalised approaches in oral surgery, such as selecting the most suitable bone graft materials, can lead to improved treatment outcomes. Filling the bone defect created after cyst removal, root resection, or extraction with a bone graft material can stabilise the weakened tooth and promote faster bone regeneration. This article shares our experiences with the therapeutic effects of albumin-coated bone allograft (BoneAlbumin^®) placed in the bone defect following cyst removal in the oral cavity, compared to cases where the defect was left untreated (controls). Methods: The study involved thirty patients who underwent the removal of maxillary odontogenic cysts. In 15 of these patients, the bone defect was filled with albumin-coated bone allograft (BoneAlbumin^®, OrthoSera, Budapest, Hungary). In the control group, which consisted of 15 patients, the defect was left untreated. A consistent surgical protocol was adhered to throughout the study. Follow-up periapical X-rays were taken immediately after surgery as well as at 6 and 12 weeks post-surgery, using a standardised template. These images were used to assess the shrinkage and healing of the defect caused by the cyst. Measurements were adjusted to reference points to account for potential distortions in the X-rays. Results: The control and study groups exhibited no statistically significant differences in their basic parameters. Additionally, there was no notable difference in the sizes of postoperative defects between the two groups. However, statistical analysis revealed a significant difference in the changes in defect size (∆defect size) between the groups at both 6 weeks (p < 0.000001) and 12 weeks (p = 0.000296). This suggests that the BoneAlbumin^®-graft group experienced significantly greater changes in defect size over time. Conclusions: The use of BoneAlbumin^® graft leads to a markedly better reduction in defect size as time progresses, although these changes have only been compared to graft-free healing.

Keywords: bone grafting; bone-albumin; cyst removal; odontogenic cyst; tissue regeneration.