Promoting HPV vaccination among adolescent girls in low-resource areas of China: A multi-centered qualitative study

Hum Vaccin Immunother. 2025 Dec;21(1):2521940. doi: 10.1080/21645515.2025.2521940. Epub 2025 Jun 26.

Abstract

The human papillomavirus (HPV) vaccine is a key preventive measure against cervical cancer, yet by 2022, the vaccination rate among 9-14-year-old girls in China remained only 4%. This study explores parental decision-making regarding HPV vaccination for girls in low-resource areas of China with mobile information influence. Qualitative interviews were conducted with parents (n = 22) from middle schools in Shanxi, Sichuan, Inner Mongolia, and Yunnan provinces using purposive sampling. Participants engaged in Health Belief Model (HBM)-based-semi-structured interviews from January to March 2024. Data was transcribed and analyzed using Haase's adaptation of Colaizzi's method. Three key themes emerged: (1) Parental protection as the primary driver-Parents' instinct to protect their daughters, combined with expanded access to online health information, reinforced their recognition of HPV vaccination as a crucial preventive measure. (2) The role of government-supported programs-Free vaccination initiatives significantly improved accessibility and affordability, fostering trust in government and scientific credibility, while collective campaigns reinforced vaccine acceptance. (3) Barriers in the mobile information era-Conflicting and unclear online information led to confusion and hesitancy. Parents expressed the need for clear, authoritative communication on vaccine safety, efficacy, age recommendations, and valency options. Government-funded vaccination programs play a vital role in the mobile era, effectively promoting HPV vaccination in low-resource areas by mitigating economic barriers, trust issues, and resource limitations. However, pervasive misinformation in the mobile era remains a barrier, highlighting the urgent need for authoritative, comprehensible health communication strategies. To promote HPV vaccination, policymakers should prioritize nationwide vaccination programs and dissemination of accurate, evidence-based public health information.

Keywords: HPV vaccine; health communication; information dissemination; low-resource areas; parental perceptions; vaccine hesitancy.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Child
  • China
  • Female
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Papillomavirus Infections* / prevention & control
  • Papillomavirus Vaccines* / administration & dosage
  • Parents / psychology
  • Patient Acceptance of Health Care
  • Qualitative Research
  • Uterine Cervical Neoplasms* / prevention & control
  • Vaccination Hesitancy / psychology
  • Vaccination* / psychology
  • Vaccination* / statistics & numerical data

Substances

  • Papillomavirus Vaccines