Alternating Cav3.2 current conducts love's pendulum

Zheyi Ni; Hailan Hu

doi:10.1016/j.cell.2025.05.036

Alternating Cav3.2 current conducts love's pendulum

Cell. 2025 Jun 26;188(13):3367-3369. doi: 10.1016/j.cell.2025.05.036.

Authors

Zheyi Ni¹, Hailan Hu²

Affiliations

¹ School of Brain Science and Brain Medicine, New Cornerstone Science Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
² School of Brain Science and Brain Medicine, New Cornerstone Science Laboratory, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: huhailan@zju.edu.cn.

PMID: 40578316
DOI: 10.1016/j.cell.2025.05.036

Abstract

The reproductive cycle in females influences their social and sexual behaviors. In this issue of Cell, Wang et al. find that the calcium channel Cav3.2 in the brain's prefrontal cortex functions as a hormone-regulated electrophysiological switch. It connects hormonal state to brain activity, enabling the processing of signals from potential male partners and facilitating sexual behavior during the reproductive period.

Publication types

Comment

MeSH terms

Animals
Calcium Channels, T-Type* / metabolism
Female
Humans
Male
Prefrontal Cortex* / metabolism
Prefrontal Cortex* / physiology
Sexual Behavior*
Sexual Behavior, Animal

Substances

Calcium Channels, T-Type