Hepatitis Viruses Hijack Cellular Metabolic Pathways to Drive Replication and Disease: Implications for Novel Therapeutics

Nanqin Peng; Qingyan Lin; Xiaotian Huang; Xiaomin Yu

doi:10.1016/j.micpath.2025.107837

Hepatitis Viruses Hijack Cellular Metabolic Pathways to Drive Replication and Disease: Implications for Novel Therapeutics

Microb Pathog. 2025 Jun 25:107837. doi: 10.1016/j.micpath.2025.107837. Online ahead of print.

Authors

Nanqin Peng¹, Qingyan Lin², Xiaotian Huang³, Xiaomin Yu⁴

Affiliations

¹ School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; HuanKui Academy, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
² School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
³ School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, School of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, China. Electronic address: xthuang@ncu.edu.cn.
⁴ School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; Medical Experimental teaching center, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China. Electronic address: yuxiaomin@ncu.edu.cn.

PMID: 40578709
DOI: 10.1016/j.micpath.2025.107837

Abstract

Hepatitis viruses are one of the most common viruses threatening humans all over the world, which can lead to viral hepatitis and even increase the risk of hepatocellular carcinoma. Numerous investigations have shown that hepatitis viruses reprogram the metabolisms of infected cells, including alterations in glucose, amino acid, and lipid metabolic pathways, resulting in changes of the life cycles of viruses, the status of host cells and the development of diseases. In this review, we summarized how hepatitis viruses rewire cells' metabolisms to promote virus replication and pathogenesis, which contributes to the exploitation of potential therapeutic paradigms.

Keywords: Hepatitis viruses; metabolic reprogramming; therapy.

Publication types

Review