Terpenoids from Aglaia edulis and their lung epithelial cells protective activity

Ling Li; Qianqian Yin; Yanping Zhang; Linlin Yang; Yue Gao; Jinle Hao; Bin Lin; Di Zhou; Ning Li

doi:10.1016/j.phytochem.2025.114599

Terpenoids from Aglaia edulis and their lung epithelial cells protective activity

Phytochemistry. 2025 Jun 25:114599. doi: 10.1016/j.phytochem.2025.114599. Online ahead of print.

Authors

Ling Li¹, Qianqian Yin¹, Yanping Zhang¹, Linlin Yang¹, Yue Gao¹, Jinle Hao², Bin Lin², Di Zhou³, Ning Li⁴

Affiliations

¹ School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China.
² Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
³ School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541000, PR China. Electronic address: zhoudi930322@163.com.
⁴ School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China. Electronic address: liningsypharm@163.com.

PMID: 40578730
DOI: 10.1016/j.phytochem.2025.114599

Abstract

A significant protective effect on lung epithelial cells was observed with the terpenoids of Aglaia edulis twigs and leaves. Lung epithelial cells protective activity guided phytochemical research afforded nineteen triterpenoids (1-19), six diterpenoids (20-25) and four sesquiterpenes (26-29), including four unreported compounds (1, 16, 20 and 22), from A. edulis. All structures were clarified by HR-ESI-MS, NMR and ECD spectra. The lung epithelial protective effect of these compounds was assessed using NNK-induced MLE-12 cells. Biological assay indicated that compounds 1-2, 4-6, 8, 10, 12-15 could reverse the damage induced by NNK in MLE-12 cells.

Keywords: Aglaia edulis; Meliaceae; NNK-induced MLE-12 cells; lung epithelial cells protective activity; terpenoids.