Simultaneous determination of nine compounds from the roots of Euphorbia fischeriana, Euphorbia ebracteolata and Stellera chamaejasme and their anti-tumor activities

Abstract

Langdu is generally considered as the roots of Euphorbia fischeriana, Euphorbia ebracteolata and Stellera chamaejasme. However, whether these three plants can substitute for one another has always been a concern. This article aims to clarify the differences among the three Langdu species in chemical constituents and anti-tumor effects. This study provides a qualitative and quantitative analysis of eight diterpenoids and one flavonoid in Langdu samples and IC₅₀ curves for these compounds, which can serve as a basis for identification and usage.

Keywords: Euphorbia ebracteolata; Euphorbia fischeriana; Stellera chamaejasme; UPLC-MS/MS; anti-tumor activity.