Association of fission 1 with multiple organ dysfunction syndrome after multiple trauma: A prospective case control study

Anjing Lu; Jin Wu; Jing Liu; Shuhong Wang; Ruilie Wang; Guang Yang; Changqiang Liang; Yuanlan Lu

doi:10.1016/j.ajem.2025.06.050

Association of fission 1 with multiple organ dysfunction syndrome after multiple trauma: A prospective case control study

Am J Emerg Med. 2025 Jun 21:96:180-186. doi: 10.1016/j.ajem.2025.06.050. Online ahead of print.

Authors

Anjing Lu¹, Jin Wu², Jing Liu³, Shuhong Wang², Ruilie Wang², Guang Yang², Changqiang Liang⁴, Yuanlan Lu⁵

Affiliations

¹ Emergency Department, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Emergency Department, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, China.
² Emergency Department, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
³ Surgery Room, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
⁴ Emergency Department, Affiliated Hospital of Zunyi Medical University, Zunyi, China. Electronic address: 657648878@qq.com.
⁵ Emergency Department, Affiliated Hospital of Zunyi Medical University, Zunyi, China. Electronic address: 1135210228@qq.com.

PMID: 40580881
DOI: 10.1016/j.ajem.2025.06.050

Abstract

Objective: Fission 1 (Fis1) plays a key role in mitochondrial division and is upregulated in pathological conditions, including trauma, sepsis, and ischemia-reperfusion injury. The goal of the study was to investigate Fis1 and other mitochondrial proteins involved in mitochondrial function and quality control as potential early biomarkers for the development of multiple organ dysfunction.

Methods: We included all multiple trauma patients presenting to the hospital within 24 h of injury from September 1, 2022 to September 1, 2023. Patients were split into two groups the non-MODS group (n = 66) and the MODS group (n = 70) We obtained serum samples from all patients and using enzyme-linked immunosorbent assay (ELISA) measured concentrations of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), Fis1, mitofusin 2 (Mfn2), and Parkin. Concentrations of proteins were compared between groups and compared to a healthy control group. Additionally, demographic data and laboratory test results were collected from the patients. We used a logistic regression to identify if biomarkers were indepenteldy associated with the development of MODS.

Results: Within 24 h of injury, the median serum concentration of Parkin, Fis1, and PGC-1α, were significantly higher in the MODS group than in the control group. Similarily, compared to the non-MODS group, the median serum concentration of Fis1 and PGC-1α were significantly higher in the MODS group. Binary logistic regression analysis, adjusted for confounding factors, identified Fis1 as a predictive biomarker for MODS (OR = 1.006, 95 % CI: 1.002-1.009, P < 0.05)The area under the curve (AUC) for Fis1 in predicting MODS after multiple trauma was 0.777 (95 % CI: 0.698-0.857), indicating a moderate diagnostic value.

Conclusion: This study found that in patients with multiple trauma, Fis1 concentrations are associated with the development of MODS.

Keywords: Fission 1; Multiple trauma;multiple organ dysfunction syndrome; Risk factors.