Visual Axis Opacification After Pediatric Cataract Surgery in the IRIS® Registry

Ju-Yeun Lee; Ju Hyun Jeon; Francisco Altamirano; Nadine AlMuasher; Tobias Elze; Joan W Miller; Alice C Lorch; Deborah K VanderVeen; Isdin Oke; IRIS® Registry Analytic Center Consortium

doi:10.1016/j.ophtha.2025.06.021

Visual Axis Opacification After Pediatric Cataract Surgery in the IRIS® Registry

Ophthalmology. 2025 Jun 27:S0161-6420(25)00392-6. doi: 10.1016/j.ophtha.2025.06.021. Online ahead of print.

Authors

Ju-Yeun Lee¹, Ju Hyun Jeon², Francisco Altamirano², Nadine AlMuasher², Tobias Elze³, Joan W Miller³, Alice C Lorch³, Deborah K VanderVeen⁴, Isdin Oke⁵; IRIS® Registry Analytic Center Consortium

Collaborators

IRIS® Registry Analytic Center Consortium:
Suzann Pershing⁶, Leslie Hyman⁷, Julia A Haller⁷, Aaron Y Lee⁸, Cecilia S Lee⁸, Joan W Miller⁹, Alice C Lorch⁹, Christina Thomas-Virnig¹⁰, Alex R Miranda¹⁰, Divya Srikumaran¹¹, Fasika A Woreta¹¹, Flora Lum¹²

Affiliations

¹ Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA; Department of Population Medicine, Harvard Medical School, Boston, MA; Department of Ophthalmology, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea.
² Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
³ Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.
⁴ Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA; Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.
⁵ Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA; Department of Population Medicine, Harvard Medical School, Boston, MA; Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA. Electronic address: Isdin.Oke@childrens.harvard.edu.
⁶ Stanford University, Palo Alto, CA.
⁷ Wills Eye Hospital, Philadelphia, PA.
⁸ University of Washington, Seattle, WA.
⁹ Massachusetts Eye and Ear and Harvard Medical School, Boston, MA.
¹⁰ University of Wisconsin, Milwaukee, WI.
¹¹ Johns Hopkins University, Baltimore, MD.
¹² American Academy of Ophthalmology, San Francisco, CA.

PMID: 40582416
DOI: 10.1016/j.ophtha.2025.06.021

Abstract

In the IRIS® Registry, approximately one-third of children developed visual axis opacification within two years of cataract surgery. Children with a history of trauma or uveitis were most likely to develop visual axis opacification.