Objective: To evaluate the value and feasibility of the lipid accumulation product (LAP) in the prediction of metabolic dysfunction-associated steatotic liver disease (MASLD) in Chinese adults with type 2 diabetes mellitus (T2DM).
Methods: In this cross-sectional study, we assessed the value of LAP and other novel indices in the prediction of MASLD in Chinese adults with T2DM in a total of 642 patients. Receiver Operating Characteristic (ROC) curves were plotted to assess the predictive ability of the indices for the occurrence of MASLD in T2DM.
Results: The results showed that LAP had a strong predictive ability for the occurrence of MASLD in T2DM in both men and women and was superior to other traditional visceral fat-related indices. In men, the area under curve (AUC) (95% CI) was 0.815 (0.771-0.859) with cut-off value of 36.01, and its sensitivity and specificity were 71.91% and 77.44%, respectively. And in women, the AUC (95% CI) was 0.816 (0.762-0.870) with cut-off value of 24.22, and its sensitivity and specificity were 84.93% and 63.54%, respectively.
Conclusion: LAP has a high predictive ability for the occurrence of MASLD in T2DM in both men and women and are superior to other traditional visceral fat-related indices.
Keywords: diabetes mellitus; lipid accumulation product; metabolic dysfunction-associated steatotic liver disease; type 2.
© 2025 Liu et al.