Deciphering the Effect of Ginsenoside Rk3 on Gut Microbiota and Its Applications

Ammu P Nair; Deepika Kaushik; Ashwani Kumar; Jyoti Singh; Emel Oz; Avinash Sharma; Ali Jebreen; Charalampos Proestos; Fatih Oz; Mukul Kumar

doi:10.1096/fj.202501234RR

Deciphering the Effect of Ginsenoside Rk3 on Gut Microbiota and Its Applications

FASEB J. 2025 Jul 15;39(13):e70784. doi: 10.1096/fj.202501234RR.

Authors

Ammu P Nair¹, Deepika Kaushik², Ashwani Kumar³, Jyoti Singh¹, Emel Oz⁴, Avinash Sharma⁵, Ali Jebreen⁶, Charalampos Proestos⁷, Fatih Oz^{4

8

9}, Mukul Kumar¹

Affiliations

¹ Department of Food Technology and Nutrition, Lovely Professional University, Phagwara, India.
² Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, India.
³ Institute of Food Technology, Bundelkhand University, Jhansi, India.
⁴ Department of Food Engineering, Faculty of Agriculture, Ataturk University, Erzurum, Türkiye.
⁵ Department of Biotechnology, Graphic Era (deemed to be University), Dehradun, India.
⁶ Department of Therapeutic Medical Nutrition, Faculty of Allied Medical Sciences, Palestine Ahliya University, Bethlehem, Palestine.
⁷ Laboratory of Food Chemistry, Department of Chemistry, School of Sciences, National and Kapodistrian University of Athens Zografou, Athens, Greece.
⁸ Department of Food Engineering, Engineering Faculty, Kyrgyz-Turkish Manas University, Bishkek, Kyrgyzstan.
⁹ East Anatolian High Technology Research and Application Center (DAYTAM), Ataturk University, Erzurum, Türkiye.

PMID: 40586417
DOI: 10.1096/fj.202501234RR

Abstract

Gut microbiota, a complex community of microorganisms residing in the gastrointestinal tract, has been implicated in the overall health and disease states of the host organism. Among various bioactive compounds, ginsenoside Rk3, a component of the medicinal plant Panax ginseng, has emerged as a potential modulator of gut microbial composition. This abstract aimed to highlight the impact of ginsenoside Rk3 on gut microbiota, uncovering its effects on microbial diversity, abundance, and functionality. By investigating the specific changes induced by ginsenoside Rk3 within the gut microbial ecosystem, the study illuminates its potential therapeutic roles, thereby expanding the understanding of host-microbiome interactions and their significance in health and disease.

Keywords: Panax ginseng; ginsenoside Rk3; gut microbiota; microorganisms.

Publication types

Review

MeSH terms

Animals
Gastrointestinal Microbiome* / drug effects
Ginsenosides* / pharmacology
Humans
Panax / chemistry

Substances

Ginsenosides